Figure 5. Dynamics of anticipatory licking behaviors and VS and TS dopamine.
Licking in response to new odors predicting reward (A) or no outcome (B) over the course of a session, in animals that have been trained with many new odor associations, as in Figure 4 (see Materials and methods). Separate plots for VS-implanted mice and TS-implanted mice are shown in Figure 5—figure supplement 1. (C) A quantification of the number of anticipatory licks elicited by each odor in VS-implanted animals (left) and TS-implanted animals (right). The difference between licks following a rewarding odor and an unrewarding odor are shown as open circles. (D) A comparison of the CS responses to rewarding and unrewarding new odors in VS dopamine (left) and TS dopamine (right). (E) A comparison of the US responses to either predicted water or predicted nothing in VS dopamine (left) and TS dopamine (right). The relationship between GCaMP responses in VS and TS and anticipatory licking is shown in Figure 5—figure supplement 2.
Figure 5—figure supplement 1. Comparison of licking in VS-implanted and TS-implanted animals.
Figure 5—figure supplement 2. Relationship between CS/US responses and anticipatory licking.
