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. 2017 Jan 25;37(1):BSR20160514. doi: 10.1042/BSR20160514

Figure 1. Modelling workflow.

Figure 1

(A) This project was initiated by a lack of agreement between simulations of a previously developed model for insulin signalling and corresponding experimental data for PKB-S473P in primary human adipocytes obtained from diabetic patients. (B) We used data from a phosphoproteomic screen in response to insulin in 3T3-L1 adipocytes to test new mechanisms that could potentially explain the human PKB-S473P data. (C) We verified the mechanisms from (B) in the model for human adipocytes in diabetes with a resulting acceptable fit with data for PKB-S473P.