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. 2017 Jan 25;37(1):BSR20160514. doi: 10.1042/BSR20160514

Figure 4. Both a positive and a negative signal from PKB to SIN1-T86P can explain time-course data, but not the increase in PKB-S473P under inhibition of mTORC1 with rapamycin.

Figure 4

(A) Model simulations of insulin stimulation (blue lines) are in agreement with extracted data from [11] (black dots ± S.E.M.). (B) Model simulations for insulin stimulation (blue lines) compared with model simulation of mTORC1 inhibition with rapamycin (cyan lines). The crossed over arrow indicates that an increase in PKB-S473P with mTORC1-inhibition is not possible to achieve with this model structure since no signals from mTORC1 to PKB-S473P are included. Shown are the model simulations for a positive signal from PKB to SIN1-T86P. Model simulations with a negative signal were similar (not shown).