Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Summary of tested hypotheses for control of mTORC2
| Experimental observations | ||||
|---|---|---|---|---|
| 3T3-L1 adipocytes [11] | 3T3-L1 and human adipocytes [39,40] | Human adipocytes [1] | ||
| Tested mechanism | Time-series data | PKB-inhibition data | PKB-S473P increase with mTORC1 inhibition | Time-series data |
| PKB → SIN1 (positive) | Ok | Ok | Fail | |
| PKB → SIN1 (negative) | Ok | Ok | Fail | |
| S6K → rictor (negative) | Ok | Ok | Ok | Fail |
| PKB → SIN1 (positive) + | Ok | Ok | Ok | Ok |
| S6K → rictor (negative) | ||||
