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. 2017 Jan 17;127(2):583–592. doi: 10.1172/JCI85499

Figure 5. LRH-1 K289R mice display increased inflammation and early signs of fibrosis upon HFHS diet feeding.

Figure 5

(A) Representative images of liver sections of K289R or WT mice stained with sirius red or CD45 to visualize collagen depositions and CD45-positive cells, respectively. Scale bars: 200 μm. CV, central vein. (B–E) Hepatic mRNA expression of genes involved in inflammation (B), matrix degradation (C), fibrosis (D), and stellate cells (E) in K289R and WT mice. n = 9 per genotype. (F) Graphical presentation showing how the LRH-1/OSBPL3 axis drives the accumulation of hepatic lipids. Error bars represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 relative to WT within each diet, as determined by 2-way ANOVA with Bonferroni’s post-hoc test (B–E).