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. 2017 Jan 17;127(2):635–650. doi: 10.1172/JCI89486

Figure 3. Loss of Bcl-w profoundly delays MYC-driven lymphomagenesis.

Figure 3

(A) Kaplan-Meier survival curves of Bcl-w+/+ Eμ-MYC, Bcl-w+/– Eμ-MYC, and Bcl-w–/– Eμ-MYC–Tg mice. P < 0.0001, comparing all 3 genotypes with each other; P < 0.0001, comparing Bcl-w–/– Eμ-MYC with Bcl-w+/+ Eμ-MYC; P = 0.0338, comparing Bcl-w+/– Eμ-MYC with Bcl-w+/+Eμ-MYC, by log-rank test. (B and C) Lymphomas of the indicated genotypes were subjected to (B) immunophenotyping to determine the type of lymphoma that emerged and (C) Western blotting to determine p53 and ARF status. Controls included a lymphoma-containing mutant p53 and p53–/– Mdm2–/– MEFs. Representative Western blots are shown; additional blots are shown in Supplemental Figure 4A. Summarized results of Western and Southern blotting are provided in Table 1.