Figure 6. Orthosteric agonists and PAMs of the M1 mAChR are equivalently efficacious in restoring fear-conditioning learning and memory deficit in prion-infected mice.

Fear-conditioning response of prion-infected mice following administration of vehicle, xanomeline (5 mg/kg), or BQCA (15 mg/kg) 30 minutes prior to training (n = 13–18). Data are shown as mean ± SEM. **P < 0.01, 1-way ANOVA.