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. Author manuscript; available in PMC: 2018 Feb 3.
Published in final edited form as: Neurosci Lett. 2016 Dec 21;639:8–12. doi: 10.1016/j.neulet.2016.12.050

Figure 2.

Figure 2

Acute administration of LY466195 had no effect on total ethanol intake or ethanol preference in Sprague Dawley (SD) rats (N=19) at the 2-hour time point. Following acute pretreatment with LY466195, Sprague Dawley rats showed no significant changes in total ethanol consumed (A), ethanol preference (B) or total fluid consumed (C). Acute administration of LY466195 significantly reduced ethanol preference alongside an increase in total fluid intake in Long Evans (LE) rats (N=6) at the 2-hour time point. Acute LY466195 pretreatment did not alter total ethanol consumed (D) but did significantly reduce ethanol preference (E) in Long Evans rats. However, there was a significant increase in the total fluid consumed following pretreatment with LY466195 when compared to vehicle (F). * p < 0.05. SD=Sprague Dawley; LD=Long Evans