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IC50 values for 1 in different human breast and cervical cancer cell lines.
| Cell Line | Antiproliferative activity of pachycladin A
|
|---|---|
| IC50 (μM)a ± S.D. (n = 3/dose) | |
| MDA-MB-231 | 1.6 ± 0.5 |
| MDA-MB-468 | 2.1 ± 1.2 |
| MCF-7 | 3.5 ± 0.9 |
| BT-474 | 7.1 ± 1.6 |
| SKBR3 | 9.5 ± 1.4 |
| T-47D | 10.6 ± 0.7 |
| HeLa (48h) | 1.7 ± 0.4 |
| HeLa (72h) | 1.3 ± 0.8 |
IC50 values were calculated using non-linear regression analysis using GraphPad Prism software.
