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Effect of Pachycladin A on the catalysis of ErbB kinases and EGFR mutant variants.
| Kinase | Mean inhibition at 10 μM (%) |
|---|---|
| EGFR (ERbB1) | 91 |
| HER2 (ERbB2) | 15 |
| HER4 (ErbB4) | 16 |
| EGFR L858R | 98 |
| EGFR L861Q | 93 |
| EGFR T790M | 93 |
| EGFR T790M L858F | 7 |
| EGFR d746-750 |
