Table 3.

Comparison of plaque burdens as a function of age, within lines (p values)

5XFAD	Kruskal-Wallis: cortex <0.0001; hippocampus <0.0001
	2–5M	6–9M	10–13M	14–17M	21–24M
2–5M	--	0.004	0.011	0.011	n.d.
6–9M	0.004	--	0.013	0.003	n.d.
10–13M	0.011	0.011	--	(>0.9999)	n.d.
14–17M	0.011	0.020	(>0.9999)	--	n.d.
21–24M	n.d.	n.d.	n.d.	n.d.	--
APPSwePS1ΔE9	Kruskal-Wallis: cortex <0.0001; hippocampus <0.0001
	2–5M	6–9M	10–13M	14–17M	21–24M
2–5M	--	<0.0006	<0.0006	<0.0006	n.d.
6–9M	<0.0006	--	<0.0006	<0.0006	n.d.
10–13M	<0.0006	<0.0006	--	<0.0018	n.d.
14–17M	<0.0006	<0.0006	<0.0006	--	n.d.
21–24M	n.d.	n.d.	n.d.	n.d.	--
rTg9191	Kruskal-Wallis: cortex <0.0001; hippocampus <0.0001
	2–5M	6–9M	10–13M	14–17M	21–24M
2–5M	--	N.A.	0.03	<0.001	<0.001
6–9M	N.A.	--	0.03	<0.001	<0.001
10–13M	0.03	0.03	--	0.009	0.004
14–17M	<0.001	<0.001	0.003	--	0.004
21–24M	<0.001	<0.001	0.004	(0.071)	--
Tg2576	Kruskal-Wallis: cortex <0.0001; hippocampus <0.0001
	2–5M	6–9M	10–13M	14–17M	21–24M
2–5M	--	N.A.	0.015	0.025	0.011
6–9M	N.A.	--	0.015	0.025	0.011
10–13M	N.A.	N.A.	--	0.008	0.001
14–17M	0.019	0.019	0.0005	--	(>0.9999)
21–24M	0.009	0.009	0.0002	0.027	--

Non-parametric analysis of variance (Kruskal-Wallis test), followed by Mann-Whitney test. P values were adjusted for multiple comparisons using the Bonferroni method. Open boxes, cortex; shaded boxes, hippocampus.

(), not significant with α = 0.05; n.d., data not available; N.A., not applicable.

Ages were binned into 4-5-month spans in order to facilitate comparisons between lines, which were studied at different ages. Exact ages studied for each line are shown in Table 1.