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(A) Schematic representation of mechanism of response of a GCaMP-type Ca2+ indicator. (B) Structure of GCaMP6m (PDB ID 3WLD) [171]. Arg376 modulates the fluorescent response upon binding to Ca2+ by electrostatic stabilization of the anionic state of the chromophore. (C) Structure of R-GECO1 (PDB ID 4I2Y) [106]. Lys78 is proposed to act similarly to Arg376 of GCaMP6m for modulation of the Ca2+-dependent fluorescent response.
