Skip to main content
. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Trends Biochem Sci. 2016 Nov 1;42(2):111–129. doi: 10.1016/j.tibs.2016.09.010

Figure 8. Two current approaches to control protein and/or cellular functions with FPs.

Figure 8

(A) FPs capable of generating ROS during illumination (photosensitizer), such as EGFP, miniSOG, KillerRed and SuperNova, can be used to disrupt the function of protein(s) of interest tethered to the photosensitizer. This is the principle of CALI. (B) Light controlled, reversible oligomerization of Dronpa can sterically block the catalytic or functional site on fusion protein. This oligomerization process is controlled with two different wavelengths of light.