Table 2.
Genotype scoring.
| Polymorphism | Allele Set |
N | Gender Distribution |
Ethnicity Distribution |
Group Distribution |
DA Signaling Capacity (score) |
|---|---|---|---|---|---|---|
| Taq1Aa | ||||||
| A1/A1 | 10 | 5 F/5 M | 0 EA, 9 AA, 1 multi |
1 HC, 1 Sib, 8 SCZ |
Low (1) | |
| A1/A2 | 47 | 26 F/21 M | 19 EA, 25 AA, 2 As, 1 AI* |
16 HC, 8 Sib, 23 SCZ |
Intermediate (1.5) |
|
| A2/A2 | 67 | 30 F/37 M | 32 EA, 32 AA, 2 multi, 1 AI*** |
17 HC, 16 Sib, 34 SCZ |
High (2) | |
| COMTval158meta | ||||||
| met/met | 27 | 13 F/16 M | 17 EA, 8 AA, 1As, 1 Multi |
5 HC, 6 Sib, 16 SCZ |
Low (1) | |
| met/val | 48 | 24 F/24 M | 16 EA, 30 AA, 1 AI, 1 multi## |
14 HC, 9 Sib, 25 SCZ |
Intermediate (1.5) |
|
| val/val | 49 | 24 F/25 M | 18 EA, 28 AA, 1 As, 1 AI, 1 multi# |
15 HC, 10 Sib, 24 SCZ |
High (2) | |
| DRD4 | ||||||
| repeats ≥ 7 |
51 | 26 F/25 M | 21 EA, 27 AA, 1 As, 1 AI, 1 Multi |
14 HC, 9 Sib, 28 SCZ |
Low (1) | |
| repeats < 7 |
73 | 35 F/38 M | 30 EA, 39 AA, 1 As, 1 AI, 2 Multi |
20 HC, 16 Sib, 37 SCZ |
High (2) | |
| SLC6A3 (DAT1) | ||||||
| 10R/10R | 68 | 35 F/33 M | 26 EA, 36 AA, 2 As, 1 AI, 3 Multi |
21 HC, 10 Sib, 37 SCZ |
Low (1) | |
| 9R/X | 56 | 26 F/30 M | 25 EA, 30 AA, 1 AI |
13 HC, 15 Sib, 28 SCZ |
High (2) | |
Abbreviations: DA, dopamine; F, female; M, male; EA, European American; AA, African American; multi, multiracial; As, Asian; AI, American Indian; HC, healthy control; SIB, sibling; SCZ, individual with schizophrenia. aResults of a univariate analysis of variance followed by Tukey’s LSD post hoc tests.
*, ***
p ≤ 0.05, 0.001 relative to A1/A1.
#, ##
p ≤ 0.05, 0.01 relative to met/met. Polymorphisms shown in bold denote a statistically significant difference in distributions between ethinicities.