Table 5.

Mediation by IQ of the effects of prenatal alcohol exposure on regional brain activations

Region	B1	B2	ta
Control > FAS/PFAS
L Anterior Cingulate	−0.62	−0.63	0.1
	−0.55	−0.50	−0.4
L Superior Frontal	−0.56	−0.50	−0.6
R Superior Frontal	−0.59	−0.46	−1.4†
	−0.54	−0.43	−0.8
R Orbitofrontal Gyrus	−0.53	−0.60	0.4
R Precentral Gyrus	−0.59	−0.53	−0.9
L Postcentral Gyrus	−0.58	−0.55	−0.3
R Postcentral Gyrus	−0.66	−0.69	0.6
L Superior Temporal	−0.74	−0.76	0.4
R Superior Temporal	−0.67	−0.55	−1.1
	−0.63	−0.50	−1.4†
L Middle Temporal	−0.55	−0.49	−0.7
R Middle Temporal	−0.62	−0.58	−0.5
	−0.52	−0.33	−1.8*
L Insula	−0.74	−0.65	−1.9*
	−0.61	−0.63	0.2
R Insula	−0.69	−0.59	−2.2*
L Fusiform Gyrus	−0.56	−0.50	−0.8
R Calcarine Sulcus	−0.62	−0.58	−0.6
L Putamen	−0.58	−0.62	0.6
Cerebellar Vermis	−0.73	−0.66	−1.6†
L Cerebellar Culmen	−0.72	−0.63	−1.4†
R Cerebellar Culmen	−0.69	−0.58	−1.4†
FAS/PFAS > Control
L Superior Frontal	0.62	0.63	−0.2
L Middle Frontal	0.56	0.60	−0.4
	0.52	0.49	0.3
R Middle Frontal	0.54	0.65	−1.1
R Cerebellar Tonsil	0.67	0.78	−2.3*

B₁ is the raw regression coefficient for the effect of prenatal alcohol exposure at the first step of the regression analysis; B₂, the coefficient for the effect at the second step.

^aDifference in coefficients method (Clogg et al, 1992)

^†p < 0.10

^*p < 0.05