Table 1.

EV interaction between cancer cells and fibroblasts

Cell types of EV donor	Cell types of EV recipient	EV components	Functions	References
Positive regulation of extracellular vesicles on cancer progression
Cancer cells	Fibroblasts	TGF-β	Triger the myofibroblast differentiation	[19]
		TGF-β	Triger the myofibroblast differentiation and promote cancer growth and angiogenesis	[20]
		Integrins	Up-regulates S100 gene expressions and promote cell growth and migration	[38]
		miR-155	Induce cancer-associated fibroblast-like phenotype through repressing TP53P1	[26]
		miR-122	Down-regulates glucose consumption of fibroblasts	[35]
Fibroblasts	Cancer cells	CD81	Enhance cancer motility and metastasis	[21]
		Extracellular matrix proteins and ADAM10	Promote cancer motility	[16]
		Non-coding of transposable RNAs	Expansion of therapy-resistant tumor-initiating cells	[23]
		miR-409	Promote epithelial-mesenchymal transition	[27]
		Wnt3a	Expansion of cancer stem cell to enhance chemoresistance	[39]
		miR-21 isomiR	Confer the chemo-resistance through targeting APAF1	[28]
		Metabolites including amino acids and lipids	Affect of metabolic properties of cancer cells	[33]