Table 2.
Effects of WMHV and CPF on change in TICS-m scores over time
| Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
| Estimate (95% CI) | P | Estimate (95% CI) | P | Estimate (95% CI) | P | |
| WMHV (%TIV) | ||||||
| Per SD increase# | −0.11 (−0.15, −0.07) | <.001 | −0.11 (−0.15, −0.07) | <.001 | −0.10 (−0.15, −0.06) | <.001 |
| Quartile 1 (<0.20) | Ref. | Ref. | Ref. | |||
| Quartile 2 (0.20-<0.35) | −0.10 (−0.21, 0.01) | 0.07 | −0.10 (−0.20, 0.01) | 0.07 | −0.09 (−0.19, 0.02) | 0.11 |
| Quartile 3 (0.35–0.72) | −0.17 (−0.28, −0.06) | 0.002 | −0.17 (−0.28, −0.06) | 0.002 | −0.13 (−0.24, −0.02) | 0.02 |
| Quartile 4 (>0.72) | −0.30 (−0.41, −0.19) | <.001 | −0.30 (−0.41, −0.19) | <.001 | −0.27 (−0.39, −0.16) | <.001 |
| Trend | <.001 | <.001 | <.001 | |||
| CPF (%TIV) | ||||||
| Per SD decrease | −0.09 (−0.14, −0.05) | <.001 | −0.09 (−0.14, −0.05) | <.001 | −0.08 (−0.12, −0.04) | <.001 |
| Quartile 1 (<70.0) | −0.31 (−0.43, −0.20) | <.001 | −0.31 (−0.43, −0.20) | <.001 | −0.28 (−0.40, −0.16) | <.001 |
| Quartile 2 (70.0–<72.8) | −0.19 (−0.30, −0.08) | <.001 | −0.19 (−0.30, −0.08) | <.001 | −0.14 (−0.25, −0.04) | 0.01 |
| Quartile 3 (72.8–75.3) | −0.08 (−0.19, 0.03) | 0.14 | −0.08 (−0.18, 0.03) | 0.15 | −0.05 (−0.16, 0.06) | 0.35 |
| Quartile 4 (>75.3) | Ref. | Ref. | Ref | |||
| Trend | <.001 | <.001 | <.001 | |||
| SBI (yes vs. no) | −0.02 (−0.13, 0.1) | 0.79 | −0.01 (−0.13, 0.1) | 0.824 | 0.09 (−0.03, 0.21) | 0.14 |
| APOE4 (yes vs. no) | −0.01 (−0.10, 0.08) | 0.83 | −0.01 (−0.10, 0.08) | 0.812 | −0.02 (−0.12, 0.07) | 0.59 |
#
log-transformed.
Model 1: Adjusted for age, age2, sex, race-ethnicity, education and medical health insurance status.
Model 2: Adjusted for age, age2, sex, race-ethnicity, education and health insurance status, smoking, moderate alcohol intake, physical activity, BMI, hypertension, diabetes, hypercholesterolemia, history of heart disease.
Model 3: Full model: including all covariates in Model 2 and WMHV, CPF, SBI and APOE genotype.