Fig. 6.
Combined antagonism of CB1R and CB2R is necessary to feminize pouncing behavior by males. A, B, Administration of AM281 or AM630 to neonatal males (PN0–3) did not alter the frequency of pouncing behavior. C–E, Coadministration of AM281 and AM630 decreased pouncing behavior by males to the level observed in females and had no effect on female play. Frequency of pouncing is an average over all days of analysis, with the average for each individual day shown in the insets (B, D, E). **p < 0.01, ***p < 0.001, n = 6–10.