Table 1.
(a) Top upregulated and (b) top down-regulated DEGs in vitiligo (VL)-blood expression profile
| Entrez ID | Gene Symbol | Gene Title | p-value | Fold-Change |
|---|---|---|---|---|
| a | ||||
| 2201 | FBN2 | fibrillin 2 | 0.0345 | 1.5 |
| 1577 | CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0315 | 1.5 |
| 23253 | ANKRD12 | ankyrin repeat domain 12 | 0.0236 | 1.4 |
| 1545 | CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0069 | 1.4 |
| b | ||||
| 9636 | ISG15 | ISG15 ubiquitin-like modifier | 0.0172 | −4.2 |
| 3434 | IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0168 | −4.0 |
| 710 | SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 0.008 | −4.0 |
| 10964 | IFI44L | interferon-induced protein 44-like | 0.0283 | −3.6 |
| 4599 | MX1 | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 0.0098 | −3.5 |
| 3437 | IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0133 | −3.5 |
| 4277 | MICB | MHC class I polypeptide-related sequence B | 0.0085 | −3.3 |
| 653361///654816///654817 | NCF1///NCF1B///NCF1C | neutrophil cytosolic factor 1///neutrophil cytosolic factor 1B pseudogene///neutrophil | 0.0436 | −2.7 |
| 8638 | OASL | 2′-5′-oligoadenylate synthetase-like | 0.0334 | −2.7 |
| 10581 | IFITM2 | interferon induced transmembrane protein 2 | 0.0342 | −2.7 |
Fold Change; a “positive” fold change indicates an upregulation and a “negative” fold change indicates a down-regulation in peripheral blood of VL patients vs. healthy controls