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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Eur J Neurosci. 2016 Oct 19;44(10):2818–2828. doi: 10.1111/ejn.13398

Figure 1. Chronic nicotine during adolescence causes deficits in adult contextual fear learning.

Figure 1

Contextual fear conditioning in mice exposed to nicotine or saline as adolescents (A) or adults (B) and tested after 30 days of abstinence. Nicotine exposure during adolescence caused deficits in contextual fear learning indicated by lower percent freezing to the context as compared to saline controls (**p < 0.01). Saline treated adults had higher levels of freezing during the immediate and preCS time points compared to saline treated adolescents (^p < 0.05). There were no differences between nicotine- and saline-exposed mice in cued fear conditioning for either age group. n=15/ experimental group.