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Striatal synaptic transmission is altered in Shank3E13 mutant mice. (A) Mean NMDA/AMPA ratio is decreased in Shank3E13 HET and KO mice. (B) Ten consecutive raw traces (gray) with overlaid average traces (black) at −70 mV (bottom) and +40 mV (top) from WT (left), HET (middle), and KO (right) mice. WT: 28 cells/9 mice, HET: 18 cells/4 mice, KO: 25 cells/5 mice (*P < 0.05, **P< 0.01, ***P < 0.001).
