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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Pharmacol Ther. 2016 Oct 19;170:166–180. doi: 10.1016/j.pharmthera.2016.10.018

Figure 6.

Figure 6

Mechanism of nucleophilic attack of a cellular nucleophile (Nuc) to the electrophilic carbon of maleylacetone. The cellular nucleophile could be a free thiol (−SH) group from cysteine present in a protein.