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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Arthritis Rheumatol. 2017 Feb;69(2):352–361. doi: 10.1002/art.39844

Figure 3.

Figure 3

Synovial hyperplasia is less severe in 22-month old mice with Mif deletion. Immunohistochemistry results for S100A8 in (A) 22-month old WT mouse, ACS score 11, and (B) 22-month old Mif−/− mouse, ACS score 0. Arrows indicate regions of strong synovial S100A8 immunopositivity and synovial hyperplasia. Representative histologic images are shown. M=meniscus. C. Synovial hyperplasia scores of the medial and lateral compartments were summed from 12-month old WT (n=5) and Mif−/− (n=5) and from 22-month old WT (n=11) and Mif−/− (n=9) mice. Horizontal lines on graph represent the mean of each group. Significant differences were determined by Kruskal-Wallis nonparametric one-way ANOVA followed by Dunn’s multiple comparisons test.