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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Arthritis Rheumatol. 2017 Feb;69(2):352–361. doi: 10.1002/art.39844

Table 1.

Histomorphometric analysis of aged mice with Mif deletion and wild-type controls.

12-month old 22-month old WT
12- vs
22-
month
olds
Parameter Mif−/−
Mean (SD)		 WT
Mean (SD)		 p-value Mif−/−
Mean (SD)		 WT
Mean (SD)		 p-value p-value
Art Cart Area
(mm2)		 0.064
(0.011)		 0.040
(0.016)		 <0.001 0.064
(0.008)		 0.029
(0.018)		 <0.001 .089
Art Cart
Thickness
(mm)		 0.072
(0.013)		 0.043
(0.017)		 <0.001 0.078
(0.009)		 0.037
(0.019)		 <0.001 .339
Subchondral
Bone Area
(mm2)		 0.080
(0.016)		 0.156
(0.069)		 0.002 0.070
(0.025)		 0.103
(0.038)		 0.009 .024
Subchondral
Bone
Thickness
(mm)		 0.059
(0.011)		 0.104
(0.046)		 0.004 0.070
(0.023)		 0.100
(0.037)		 0.013 .772
Number of
Viable
Chondrocytes		 138.39
(16.15)		 74.31
(41.38)		 <0.001 115.50
(21.98)		 64.14
(45.24)		 0.001 .549
Area of
chondrocyte
necrosis
(mm2)		 0.008
(0.006)		 0.006
(0.004)		 0.396 0.008
(0.011)		 0.007
(0.008)		 0.859 0.602
Calcified
cartilage area
(mm2)		 0.063
(0.012)		 0.059
(0.019)		 0.504 0.049
(0.005)		 0.053
(0.019)		 0.368 .421

Histomorphometry measurements of cartilage (Cart) and bone parameters in the medial tibial compartment of mid-coronal stifle sections were analyzed using the Osteomeasure Histomorphometry Program (OsteoMetrics®). 12-month old WT: n=13; 12-month old Mif−/−: n=13; 22-month old wild-type (WT): n=14; 22-month old Mif−/−: n=16. Significance differences determined by heteroscedastic t-test using SPSS.