In vivo healthy QSM estimated with COSMOS, PDF+LFI, SSQSM, Differential QSM and proposed TFI. Both PDF+LFI and TFI give more complete depiction of superior sagittal sinus than SSQSM or Differential QSM, especially at posterior brain boundary (hollow arrow). At the bottom of the cerebrum (solid arrow), TFI’s result is more homogeneous than PDF+LFI.