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Ent-cholesterol blunted alcohol-induced constriction of rat cerebral artery. (A) Original trace showing changes in middle cerebral artery diameter in response to 60 mM KCl, 50 mM ethanol, and Ca2+-free solution in ent-cholesterol-enriched vessel. (B) Averaged constriction by 60 mM KCl (n ≥ 6). (C) Averaged constriction by 50 mM ethanol (n ≥ 6). (D) Averaged constriction by ethanol as percentage of corresponding constriction by KCl. In B–D, * different from naïve cholesterol (P < 0.05).
