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. Author manuscript; available in PMC: 2018 Jan 18.
Published in final edited form as: J Am Chem Soc. 2016 Dec 30;139(2):639–642. doi: 10.1021/jacs.6b12511

Figure 1.

Figure 1

Potent, specific and rapid labeling of a cellular protein by the electrophilic probe 1 in 293 cells. (A) Structures of an electrophilic quinazoline 2 and its clickable analog (1). (B) Dose response of live cell labeling revealed potent engagement of probe 1 to an unknown cellular target of ~70 kDa (p70). (C) Time-course experiment showed rapid engagement of 1 to p70. (D) Dose-dependent blockade of probe labeling by pre-treatment of 2.