Table 4.

Coefficient table and summary of fit of the models obtained for the mAb charge variants and one glycan variant

	pH	pO2	pCO2	pH2	pO22	pCO22	pH × pCO2	R 2	Q 2	MV	RP
(i) ACV 1	−0.44	–	0.37	0.24	–	0.28	−0.22	0.67	0.57	0.78	0.67
(ii) ACV 2	0.94	–	−0.04	–	–	–	−0.15	0.92	0.84	0.94	0.86
(iii) BCV 1	−0.65	0.13	0.17	–	0.27	0.29	–	0.87	0.72	0.59	0.90
(iv) BCV 2	0.74	–	–	−0.58	–	–	–	0.72	0.60	0.38	0.90
(v) BCV 3	−0.88	–	–	–	–	–	–	0.77	0.73	0.68	0.85
(vi) BCV 4	−0.73	–	0.41	–	–	–	–	0.78	0.71	0.78	0.81
sum of basic variants	−0.64	0.19	0.17	–	0.22	0.3	–	0.82	0.59	0.64	0.84
bG1FSA_2	−0.03	–	−0.26	0.67	–	–	−0.48	0.76	0.53	0.84	0.68

The coefficients according to the individual factors of the DoE are normalized. Coefficients that are shown in italic are not considered as significant regarding the applied significance. Acidic charge variants (ACV), basic charge variants (BCV) and one glycan variant are presented