Table 2.
Percentage change in lipid parameters based on C3435T genotype in ABCB1 and G2012T in ABCC1 in each dosage group after four weeks of atorvastatin therapy
| Variables | ABCC1 | P value | ABCB1 | P value | ||
|---|---|---|---|---|---|---|
| GG | GT+TT | CC | CT+TT | |||
| First groupa | ||||||
| LDL-C | -37±11 | -33±13 | 0.02 | -23±10 | -35±12 | 0.01 |
| HDL-C | 6±2 | 8±1 | 0.11 | 7±3 | 8±3 | 0.73 |
| Triglyceride | -17±10 | -18±12 | 0.82 | -10±6 | -8±8 | 0.22 |
| Total cholesterol | -26±12 | -23±13 | 0.06 | -22±10 | -24±11 | 0.26 |
| Second groupb | ||||||
| LDL-C | -43±12 | -43±11 | 0.81 | -44±11 | -43±11 | 0.63 |
| HDL-C | 6±4 | 7±2 | 0.26 | 7±5 | 7±4 | 0.85 |
| Triglyceride | -17±8 | -20±4 | 0.16 | -20±10 | -18±9 | 0.55 |
| Total cholesterol | -30±15 | -29±13 | 0.29 | -30±14 | -29±13 | 0.53 |
a
n=104; atorvastatin 10 mg/day);
b
n=75; atorvastatin 20 and 40 mg/day; LDL-C, low density lipoproteins-cholesterol; HDL-C, high density lipoproteins cholesterol (the mean percentage change±SD, mg/dl)