Skip to main content
. Author manuscript; available in PMC: 2017 Jan 29.
Published in final edited form as: Free Radic Biol Med. 2014 Nov 22;79:324–336. doi: 10.1016/j.freeradbiomed.2014.11.012

Figure 1.2. Metabolic regulations by p53.

Figure 1.2

p53 inhibits glycolysis by downregulation of glycolytic enzyme, glucose transportor (GLUTs), and F-2,6-BP, a glycolysis activator. Mitochondrial oxidative phosphorylation (OXPHOS) is also maintained by p53 through facilitating cytochrome c oxidase (CcO) assembly. Increasing conversion of pyruvate to acetyl-CoA and transcription of glutaminase for glutaminolysis ultimately elevate the metabolites in the TCA cycle. p53 also inhibits fatty acid synthesis and activates fatty acid oxidation.