Figure 2. Cumulative distribution of the genetic risk score (GRS) for type 2 diabetes in Pimas and in each of the HapMap populations (Han Chinese in Beijing (CHB), Utah residents with ancestry from northern and western Europe (CEU) and Yoruba in Ibadan (YRI)).

In the left panel (A), the GRS was calculated as the sum of the number of risk alleles across 63 type 2 diabetes loci, while in the right panel (B) it is the sum of the number of risk alleles multiplied by log (OR), as determined in Europeans. Differences in the mean GRS (µ) between populations were compared in a mixed model in which population was a fixed effect and sibship was a random effect. Modified from [131].