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. Author manuscript; available in PMC: 2017 Jan 29.
Published in final edited form as: Biochemistry. 2016 Nov 1;55(45):6258–6268. doi: 10.1021/acs.biochem.6b00715

Figure 1.

Figure 1

(a) Putative orientation of CYP3A4 in the lipid bilayer. This representation is consistent with many MD simulations and H/DX mass spectrometry. The N-terminal helix is expected to insert deeply into the membrane, whereas the F′ and G′ helices insert less deeply (Protein Data Bank entry 1TQN11). The structures of (b) POPC and (c) DMPC are also shown.