Table 1.
Neurotrophin signaling pathway targeted genes and expression level in Oral squamous cell carcinoma and normal tissue in TCGA samples. FDR is false discovery rate
| Gene | Fold Change | Tumor Level | Nontumor Level | FDR |
|---|---|---|---|---|
| CAMK2D | No Change | |||
| BRAF | No Change | |||
| GSK3B | 1.36 | 1929 | 1416 | 0.00082 |
| NTRK2 | 0.29 | 416 | 1460 | 0.01 |
| NFKB1 | No Change | |||
| SOS2 | NA | |||
| RAPGEF1 | No Change | |||
| SH2B3 | 1.67 | 656 | 392 | 0.0016 |
| NRAS | 1.55 | 2175 | 1400 | 0.00001 |
| CRKL | 1.62 | 3560 | 2196 | 0.0000024 |
| PIK3CB | No Change | |||
| MAPK7 | No Change | |||
| MAP2K7 | No Change | |||
| SORT1 | 0.37 | 1422 | 3810 | 0.0000001 |
| PIK3R2 | 1.07 | 0.45 | ||
| BCL2 | 0.42 | 131 | 311 | 0.000013 |
| MAP3K1 | 0.69 | 747 | 1076 | 0.0044 |
| NGFRAP1 | 1.63 | 1564 | 958 | 0.000418 |
| MAGED1 | No Change | |||
| ARHGDIB | No Change | |||
| FASLG | No Change | |||
| MAPK13 | 0.76 | 1579 | 2075 | 0.173 |
| RPS6KA5 | 0.62 | 176 | 286 | 0.0005 |
| TP53 | 0.69 | 966 | 1406 | 0.102 |
| PLCG1 | 1.64 | 1409 | 862 | 0.0000001 |
| PIK3CD | 2.65 | 859 | 323 | 0.0000001 |
| JUN | 0.81 | 6250 | 7702 | 0.193 |
| PIK3R3 | 0.59 | 385 | 650 | 0.0022 |
| TRAF6 | No Change | |||
| AKT1 | No Change | |||
| RPS6KA6 | 0.066 | 1.98 | 30 | 0.0000001 |
| PIK3R1 | 0.42 | 851 | 2024 | 0.0000002 |
| IRS1 | 1.86 | 1487 | 800 | 0.000447 |
| CDC42 | No Change | |||
| PLCG2 | 1.3 | 407 | 313 | 0.0922 |
| GAB1 | 0.69 | 595 | 868 | 0.00469 |
| AKT3 | 1.52 | 292 | 192 | 0.034 |
| PIK3CA | 1.52 | 642 | 423 | 0.000438 |
| FOXO3 | No Change | |||
| SH2B1 | 0.69 | 617 | 891 | 0.00033 |
| IRAK1 | 1.57 | 4523 | 2883 | 0.000008 |
| ABL1 | No Change | |||
| ATF4 | 0.75 | 4968 | 6651 | 0.0015 |
| MAP3K5 | 1.18 | 786 | 667 | 0.197 |