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. 2016 Aug 26;173(19):2859–2879. doi: 10.1111/bph.13562

Figure 7.

Figure 7

ASCs or CM treatment attenuates lung fibrosis and tissue remodelling in the Bleo animals (Early phase). ASCs or CM were injected through the jugular vein after 3 days of Bleo‐instillation. Following 2 weeks of Bleo‐instillation, animals were sacrificed, and the lungs were stained with PS and H&E staining to assess lung fibrosis and tissue remodelling. (A) and (C) represent the improvement of pulmonary fibrosis in the Bleo animals in presence of ASCs or CM. Scale bar = 100 μm. (B) and (E) represent the improvement of lung tissue remodelling in the Bleo animals in presence of ASCs or CM. Scale bar = 200 μm. (D) Demonstrates the attenuation of collagen deposition (hydroxyl proline) in the presence of ASCs or CM in the Bleo animals. Data presented in (C)‐(E) are mean ± SEM (n = 5). * P value of ≤ 0.05, comparing B and B + M animals against the controls. # P value of ≤ 0.05, comparing BAD3 and BCM3 versus B. @ P value of ≤ 0.05, comparing BCM3 versus B + M.