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. 2016 Aug 26;173(19):2859–2879. doi: 10.1111/bph.13562

Figure 8.

Figure 8

ASCs or CM treatment arrests the progression of established lung fibrosis and tissue remodelling in Bleo animals (Late phase). ASCs or CM were injected through the jugular vein after 7 days of Bleo‐instillation. Following 2 weeks of Bleo‐instillation, animals were killed, and the lungs were stained with PS and H&E. (A) and (C) represent the anti‐fibrotic effects of ASCs or CM. Scale bar = 100 μm. (B) and (E) improvement of lung tissue remodelling in the Bleo animals in presence of ASCs or CM. Scale bar = 200 μm. (D) Attenuation of collagen deposition as measured by lung hydroxyl proline content by ASCs or CM treatment. Data presented in (C)–(E) are mean ± SEM (n = 5). * P value of ≤ 0.05, comparing B and B + M animals against the controls. # P value of ≤ 0.05, comparing BAD7 and BCM7 versus B. @ P value of ≤ 0.05, comparing BCM7 versus B + M.