Figure 1. A scheme of the mitochondrial model .

Allosteric regulation by Ca²⁺ and P_i is indicated by red and blue arrows, respectively. Shown inside the dotted box are additional cytoplasmic and plasmalemmal components to simulate an in vivo workload change of cardiomyocytes with mitochondria incorporated. AcCoA, acetyl‐CoA; ALA, alanine; ANT, adenine nucleotide translocase; ASP^–, aspartate; C1, Complex I of the respiratory chain; C3, Complex III of the respiratory chain; C4, Complex IV of the respiratory chain; CS, citrate synthase; Cytco, oxidized form of cytochrome c; Cytcr, reduced form of cytochrome c; FH, fumarate hydratase; FUM^2–, fumarate; GLU^–, glutamate; HCIT^2–, citrate; MAL^2–, malate; NDK, nucleoside diphosphate kinase; OAA^2–, oxaloacetate; OG^2–, 2‐oxoglutarate; PYR^–, pyruvate; SDH, succinate dehydrogenase; SUC^2–, succinate; UQH2; ubiquinol; ScCoA, succinyl‐CoA.