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Two contrasting examples how nitrosylation and sulfhydration of proteins affect the biological processes. (A) sulfhydration of GAPDH leads to degradation of PSD95 via Siah. In contrast nitrosylation of GAPDH leads to cell death via activating p300/CBP and p53 signaling axis. (B) sulfhydration of p65 interacts with RPS3 and facilitates transcriptional activation of p65. On the other hand, nitrosylation of p65 prevents its transcriptional activation.
