FIGURE 1.

Clinical manifestations in IFNAR^-/- mice infected with SFTSV. Groups of four IFNAR^-/- mice were infected with a high dose (10⁵ TCID₅₀/mouse) or low dose (10² TCID₅₀/mouse) of the SFTSV strain SD4, intradermally (i.d.), intraperitoneally (i.p.), intramuscularly (i.m.), or subcutaneously (s.c.). The mice were monitored daily to assess survival (A) and body weight (B) and results until 6 days post inoculation (dpi) were shown. The blood from the infected mice euthanized because they reached the humane endpoint and the uninfected mice euthanized at 6 dpi were subjected to virus titration (C) and hematological examinations, i.e., lymphocyte count (D), platelet count (E), and mean platelet volume (F). All values are indicated as means ± SD. ^∗P < 0.05, compared with uninfected controls.