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. 2017 Jan 30;8:104. doi: 10.3389/fmicb.2017.00104

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Copyright © 2017 Matsuno, Orba, Maede-White, Scott, Feldmann, Liang and Ebihara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Colocalization of host cell markers and SFTSV antigen in SFTSV-infected tissues from IFNAR^-/- mice. The spleen (A) lymph node (B), liver (C), and kidney (D) of the SFTSV-infected mice were subjected to double staining with anti-SFTSV N antibodies and host cellular markers: CD3e (T cells), IbaI (macrophages), Pax5 (immature B cells), and gp36 (reticular cells). Cells stained with both SFTSV and host cellular markers are indicated by arrowheads, and the phagocytosis of an infected cell by an IbaI-positive macrophage is indicated by an arrow.