Table 1.
Summary of animal models of human-pathogenic tick-borne phleboviruses.
| Virus | Animal | Strain | Outcome/Disease | Reference |
|---|---|---|---|---|
| SFTSV | Mouse | 129S1/SvlmJ | Non-lethal | Present study |
| 129S1/SvlmJ (aged 1 yr) | Non-lethal | Present study | ||
| IFNAR-/- 129/Sv | Lethal | Liu et al., 2014; Shimada et al., 2015 | ||
| A/J | Non-lethal | Present study | ||
| BALB/c | Non-lethal | Chen et al., 2012; Jin et al., 2012 | ||
| BALB/c (newborn) | Lethal | Chen et al., 2012 | ||
| BXD34/TyJ | Non-lethal | Present study | ||
| BXD68/RwwJ | Non-lethal | Present study | ||
| C57BL/6 | Non-lethal weight loss | Chen et al., 2012; Jin et al., 2012, Present study | ||
| C57BL/6 (newborn) | Lethal | Chen et al., 2012 | ||
| C57BL/6 (aged 1 year) | Non-lethal weight loss | Present study | ||
| C57BL/6 (aged 2 year) | Non-lethal weight loss | Present study | ||
| C57BL/6 (mitomycin C treatment) | Lethal | Jin et al., 2012 | ||
| IFNAR-/- C57BL/6 | Lethal | Tani et al., 2015, Present study | ||
| CAST/EiJ | Non-lethal | Present study | ||
| CD-1 | Non-lethal | Liu et al., 2014, Present study | ||
| CD-1 (newborn) | Non-lethal | Liu et al., 2014 | ||
| DBA/1J | Non-lethal | Present study | ||
| DBA/2J | Non-lethal | Present study | ||
| FVB/NJ | Non-lethal | Present study | ||
| Kunming | Non-lethal | Chen et al., 2012 | ||
| Kunming (newborn) | Lethal | Chen et al., 2012 | ||
| NZBWF1/J | Non-lethal | Present study | ||
| SJL/J | Non-lethal | Present study | ||
| Hamster | Syrian hamster | Non-lethal | Jin et al., 2012 | |
| Golden hamster | Non-lethal | Chen et al., 2012; Liu et al., 2014 | ||
| Golden hamster (newborn) | Non-lethal | Chen et al., 2012; Liu et al., 2014 | ||
| Rat | Wistar | Non-lethal | Chen et al., 2012 | |
| Wistar (newborn) | Non-lethal | Chen et al., 2012 | ||
| Rhesus macaque | Non-lethal | Jin et al., 2015 | ||
| Cynomolgus macaque | Non-lethal | Present study | ||
| HRTV | Cynomolgus macaque | Non-lethal | Present study |