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. 2016 Dec 1;108(1):116–123. doi: 10.1111/cas.13112

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© 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Schematic diagram of vector construction. These vectors are constructed from an E3 region‐deleted Ad5 backbone and do not contain the Ad E1A promoter region (from nucleotide 324 to 488 of the Ad genome). Deletion of the E3 region was necessary because the 2.6 kb VEGF promoter we chose was too long to insert into the Ad genome without deletion of the adenoviral E3 region. Ad5CMVE1 and Ad5VEGFE1 differ in the promoter driving E1A expression. We also constructed fiber modified Ad5/3VEGFE1 and Ad5/3CMVE1.