Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 1;108(1):116–123. doi: 10.1111/cas.13112

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Tumor growth suppression: pre‐infection with Ad5VEGFE1 in vitro. NCI‐H226 cells (1 × 10⁷) were pre‐infected with Ad5VEGFLuc (as control; a) or Ad5VEGFE1 (b) and mixed with non‐infected cells in various percentages before implantation. Mice were sacrificed at 7 weeks after implantation. (a) No effect of tumor suppression was seen in control mice (50% infected with Ad5VEGFLuc). (b) Tumor formation was suppressed when cells were infected with Ad5VEGFE1 (10% infected with Ad5VEGFE1). (c) Survival time of (a) or (b). (d) Tumor growth suppression by Ad5/3VEGFE1 in vivo. Two weeks after implantation of H226 cells (1 × 10⁷), mice (n = 6) received a single injection of 1 × 10⁸ pfu of Ad5/3VEGFE1. Control mice (n = 6) received the same dose of Ad5/3CMVLuc. Improvement of survival time by Ad5/3VEGFE1 was observed (P = 0.1092).