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Diagram summarizing the proposed relationship between aging, nutrition and neural stem cells. Aging and dietary modulation such as calorie restriction (CR) can alter the composition of the systemic environment, which affects epigenetic regulation and several nutrient-sensing pathways, including the mTOR, Sirtuin and Insulin and Insulin like signaling (IIS) pathways. These in turn alter neural stem cell (NSC) regulation and can predispose to disease and cognitive decline.
