Skip to main content
. 2017 Jan 30;8:98. doi: 10.3389/fmicb.2017.00098

FIGURE 2.

FIGURE 2

Multiple Sir2p agonists and an antagonist altered the RLS of H99. (A) INAM extended the median RLS of H99 cells in NA-depleted conditions by 46%, (B) resveratrol by 32%, (C) SirAct by 41%, and (D) SRT1460 by 39%, respectively (all p < 0.04). In contrast (E) 1–10 pM SRT1720 failed to extend the median RLS of H99 cells or was toxic to Cryptococcus neoformans. As expected, the SIR2 antagonist (F) sirtinol significantly shortened the median RLS of H99 cells by 20% (p = 0.006). RLS experiments with the respective drug (n = 40–60 cells) were performed at the same time. p-values were calculated by Wilcoxon Rank Sum Test.