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. 2017 Jan 30;8:98. doi: 10.3389/fmicb.2017.00098

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Copyright © 2017 Bouklas, Jain and Fries.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adjunctive treatment of Sir2p agonists with amphotericin B enhanced antifungal efficacy. Treatment with Sir2p agonists, (A) INAM or (C) resveratrol, and 0.06 μg/ml AMB enhanced antifungal efficacy in H99-infected worms. (B,D) Lifespan effects were dependent on Sir2p and not observed when infections were done with sir2Δ cells. (E) The Sir2p antagonist (sirtinol) had a reverse, albeit minimal, effect that was notably (F) Sir2p-dependent. Virulence experiments with the respective drug (n = 20–40 worms) represent duplicate experiments and were performed with the respective mutant at the same time. p-values were calculated by Log-Rank test.