TABLE 1.
Performance characteristics of selected host gene expression signatures for bloodstream and respiratory infections
| Reference | Disease state | Disease state(s) of comparative control group | No. of genes in signature | No. of subjects in validation group | Accuracy | Sensitivity | Specificity |
|---|---|---|---|---|---|---|---|
| 14 | Sepsis | Noninfectious SIRS | 4 | 59 | 0.86 | 0.79 | 0.91 |
| 17 | Viral infection (influenza) | Bacterial infection (S. pneumoniae) | 30 | 33 | 0.93 | —a | — |
| 8 | Viral infection (influenza) | Bacterial infection (E. coli, S. pneumoniae) | 35 | 75 | 0.91 | — | — |
| 8 | Gram-positive bacterial infection (S. pneumoniae) | Gram-negative bacterial infection (E. coli) | 30 | 40 | 0.85 | — | — |
| 18 | Viral infection (RSV) | Viral infection (HRV, influenza virus) | 70 | 137 | 0.95 | 0.94 | 0.98 |
| 26 | Fungal infection (Candida albicans) | Bacterial infection (S. aureus) and uninfected | 67 | 72 | 0.97 | 0.98 | 0.96 |
a
Sensitivity and specificity not provided in reference.