TABLE 3.
Comparison of the DDM to reference BMD
| Genus (no.) | No. of measurements with log2 difference from reference MICa |
% agreement (95% CI) |
% error category (95% CI) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| −2 | −1 | 0 | 1 | 2 | 3 | Evaluable essential | Overall essential | Categorical | Minor error | Major error | Very major error | |
| Escherichia (41) | 0 | 6 | 53 | 40 | 9 | 1 | 90.8 (83.9–94.9) | 88.6 (82.1–93.0) | 84.1 (76.9–89.4) | 15.9 (10.6–23.1) | 0 | 0 |
| Klebsiella (11) | 1 | 4 | 14 | 10 | 3 | 0 | 87.5 (71.9–95) | 89.1 (75.3–95.7) | 94.5 (82.3–95.5) | 5.4 (1.5–17.8) | 0 | 0 |
| Other (12) | 0 | 3 | 5 | 10 | 0 | 0 | 100 (82.4–100) | 89.4 (75.7–95.8) | 84.2 (69.6–92.6) | 15.7 (7.4–30.0) | 0 | 0 |
| Total no. (%, CI)b | 1 (0.6) | 13 (8.2) | 72 (45.3) | 60 (37.8) | 12 (7.5) | 1 (0.6) | 145 (91.1, 85.8–94.7) | 184 (88.9, 83.9–92.5) | 178 (86.0, 80.6–90.1) | 29 (14.0, 9.9–19.4) | 0 | 0 |
a
Includes only comparisons in which both the DDM result and the reference MIC were on scale (within the range of dilutions tested).
b
Numerical tabulations include comparison of all individual DDM measurements as applicable, performed in replicate for each strain as described in the Materials and Methods section, to the reference MIC (leading to a total of 207 comparisons for determination of categorical agreement and minor errors).