TABLE 1.
Enterobacteriaceae group | Resistance mechanism | No. of isolates | MIC range (μg/ml) for: |
Test results (no.) fora: |
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Meropenem | Imipenem | Ertapenem | BYG |
BCT |
RCNP |
NRCK |
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P | N | P | D | N | P | D | N | NI | P | D | N | NI | ||||||
CPE | KPC-3 | 8 | 4–>32 | 16–>32 | 12–>32 | 8 | 0 | 7 | 1 | 0 | 8 | 0 | 0 | 0 | 8 | 0 | 0 | 0 |
NDM-1 | 18 | 3–>32 | 2–>32 | 6–>32 | 18 | 0 | 18 | 0 | 0 | 18 | 0 | 0 | 0 | 18 | 0 | 0 | 0 | |
VIMb | 13 | 1–32 | 4–>32 | 0.19–>32 | 13 | 0 | 13 | 0 | 0 | 13 | 0 | 0 | 0 | 13 | 0 | 0 | 0 | |
OXA-48 | 69 | 0.19–>32 | 0.38–>32 | 0.25–>32 | 69 | 0 | 67 | 2 | 0 | 60 | 9 | 0 | 0 | 57 | 9 | 2 | 1 | |
NDM-1 + OXA-48 | 2 | >32 | >32 | >32 | 2 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | |
KPC-2 + VIM-1 | 1 | >32 | >32 | >32 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | |
Total CPE | 111 | 0.19–>32 | 0.38–>32 | 0.19–>32 | 111 | 0 | 108 | 3 | 0 | 102 | 9 | 0 | 0 | 99 | 9 | 2 | 1 | |
Non-CPE | ESBL | 29 | 0.016–24 | 0.125–3 | 0.006–>32 | 0 | 29 | 0 | 0 | 29 | 0 | 6 | 23 | 0 | 0 | 2 | 26 | 1 |
AmpC overexpression | 30 | 0.023–12 | 0.125–32 | 0.19–>32 | 1 | 29 | 0 | 1 | 29 | 0 | 5 | 25 | 0 | 0 | 1 | 25 | 4 | |
ESBL and AmpC overexpression | 13 | 0.047–4 | 0.19–16 | 0.094–>32 | 0 | 13 | 0 | 0 | 13 | 0 | 2 | 11 | 0 | 0 | 1 | 12 | 0 | |
Narrow spectrum β-lactamases | 15 | 0.012–4 | 0.19–2 | 0.003–24 | 0 | 15 | 0 | 1 | 14 | 0 | 1 | 14 | 0 | 0 | 0 | 15 | 0 | |
Total non-CPE | 87 | 0.012–24 | 0.125–32 | 0.003–>32 | 1 | 86 | 0 | 2 | 85 | 0 | 14 | 73 | 0 | 0 | 4 | 78 | 5 |
BYG, BYG Carba test, BCT, β Carba test, RCNP, Rapidec Carba NP test, NRCK, Neo-Rapid Carb screen kit; P, positive; N, negative; D, doubtful; NI, noninterpretable.
VIM-1 (n = 12), VIM-4 (n = 1).