TABLE 4.
Sensitivity and specificity for detecting CIN2+ and CIN3+ using cobas 4800 HPV testing with LBC and swab samples
| Storage time and sample type | CIN2+ |
CIN3+ |
||
|---|---|---|---|---|
| Sensitivity (% [95% CI]) | Specificity (% [95% CI]) | Sensitivity (% [95% CI]) | Specificity (% [95% CI]) | |
| Total (n = 659) | ||||
| LBC | 91.4 (87.2–94.3) | 53.7 (48.9–58.5) | 92.9 (88.4–95.7) | 49.8 (45.2–54.3) |
| Swab | 93.4 (89.6–95.9) | 52.8 (48.0–57.5) | 93.9 (89.7–96.5) | 48.3 (43.7–52.8) |
| Storage for 2 days (n = 161) | ||||
| LBC | 89.5 (78.9–95.1) | 56.7 (47.1–65.9) | 89.6 (77.8–95.5) | 53.1 (44.0–62.0) |
| Swab | 89.5 (78.9–95.1) | 55.8 (46.2–64.9) | 89.6 (77.8–95.5) | 52.2 (43.1–61.2) |
| Storage for 7 days (n = 170) | ||||
| LBC | 96.7 (88.8–99.1) | 53.2 (43.9–62.3) | 98.0 (89.5–99.7) | 49.2 (40.4–58.0) |
| Swab | 98.4 (91.3–99.7) | 51.4 (42.1–60.6) | 98.0 (89.5–99.7) | 46.7 (38.0–55.6) |
| Storage for 14 days (n = 164) | ||||
| LBC | 86.7 (75.8–93.1) | 57.7 (48.1–66.8) | 91.1 (79.3–96.5) | 53.8 (44.9–62.5) |
| Swab | 93.3 (84.1–97.4) | 56.7 (47.1–65.9) | 95.6 (85.2–98.8) | 51.3 (42.4–60.1) |
| Storage for 28 days (n = 164) | ||||
| LBC | 92.4 (83.5–96.7) | 46.9 (37.4–56.8) | 92.6 (82.5–97.1) | 42.7 (33.9–52.1) |
| Swab | 92.4 (83.5–96.7) | 46.9 (37.4–56.8) | 92.6 (82.5–97.1) | 42.7 (33.9–52.1) |