Fig. 1.

Visualization of the analysis pipeline. (A) depicts an exemplar patient MR image in the top row (coronal, axial and sagittal views), with the second row containing the lesion mask and the third row indicating the automated anatomical labelling (AAL) atlas regions in native space. In (B), the hub regions, i.e. those areas belonging to the default mode network (DMN, blue) and the frontoparietal network (FPN, red), are displayed on a surface plot. Grey areas are non-hub regions. (C) depicts our first main outcome parameter, namely frequency distribution. This is a smoothed curve depicting connection strength distribution for a single subject, based on the binning of each element in the adjacency matrix. In (D), the second set of outcome parameters is indicated. The connections between hubs (red), between hubs and non-hubs (blue), and between non-hubs (green) were used to obtain three averages in each subject. Hubs are displayed as larger circles while non-hub regions are represented by the smaller circles. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)